Inexpensive DIY MtF HRT

I began MtF HRT in 1989, had SRS in 1999. Injectable estradiol valerate and transdermal estradiol don't affect liver and blood clotting at all, but transdermals are much more expensive. When I was on factory-made injectable estradiol valerate, I developed an allergy to some impurity in it. Because of that, I began to compound injectable estradiol valerate for myself by myself at home: I mix estradiol valerate powder, a preservative (antibacterial) and a solvent (all pharmaceutical quality, from pharmaceutical trade companies) in multi-dose vials, add Castor oil from a pharmacy or MCT oil (you can choose, MCT oil is less viscous but Castor oil gives more stable blood estradiol level) and sterilize sealed vials. After I tested on myself, in 2006 I began to sell to other MtF. In October 2017 I began to ship worldwide.

I sell ready-to-use vials with estradiol valerate solution 400 mg/vial (10 ml/vial 40 mg/ml) sterilized at 129úC for 60 USD/vial, 2 to 8 vials per purchase, currently expiration March 2026. Shipping 8 USD. For example, delivery to USA with USPS registered mail, tracked, shipping times for regular shipping option, days: 20, 12, 16, 11, 11, 13, 14, 16, 14, 10, 8, 7, 12, 7, 9, 15, 13, 9, 10, 8, 10, 11, 10, 8, 8, 10, 11, 14, 14, 18, 21, 25, 20, 8, 26, 21, 18, 28, 15, 16, 18, 22, 23, 18, 19, 20, 21, 33, 26, 22, 18, 26, 26, 19, 18, 18, 28, 20, 21, 18, 15, 13, 12, 16, 11, 16, 20, 19, 21, 13, 14, 16, 12, 21, 23, 12, 12, 22, 14, 13, 16, 16, 16, 13, 11, 37, 14, 14, 17, 13, 13, 13, 13, 13, 16, 24, 24, 20, 13, 14, 18, 17, 15, 14, 17, 12, 15, 13, 14, 15, 19, 13, 11, 14, 14, 14, 17, 11, 9, 10, 11, 10, 20, 8, 16, 11, 10, 17, 11, 11, 25, 11, 15, 11, 11, 15, 11, 12, 11, 11, 11, 7, 9, 8, 6, 9, 20, 11, 11, 8, 8, 8, 9, 7, 6, 10, 7, 8, 12, 5, 7, 10, 6, 7, 7, 10, 7, 8, 8, 8, 8, 10, 12, 12, 7, 12, 8, 9, 7, 9, 7, 7, 9, 10, 8, 7, 10, 6, 9, 10, 7, 11, 6, 9, 9, 8, 7, 6, 8, 7, 7, 7, 9, 9, 6, 7, 11, 6, 7, 8, 10, 10, 11, 11, 13, 9, 8, 11, 7, 11, 11, 8, 8, 8, 13, 14, 9, 8, 14, 13, 9, 11, 10, 7, 11, 9, 13, 10, 12, 11, 12, 24, 12, 15, 15, 9, 9, 18, 13, 15, 13, 15, 9, 7, 7, 10, 9, 11, 12, 10, 10, 12, 12, 28, 15, 16, 10, 23, 13, 13, 13, 14, 20, 14, 22, 22, 25, 23, 20, 17, 13, 23, 30, 15, 29, 19, 37, 39, 36, 32, 9, 15, 22, 40, 27, 41, 37, 44, 22, 11, 12, 25, 42, 35, 14, 16, 38, 29, 41, 19, 31, 20, 34, 24, 27, 17, 31, 20, 23, 28, 35, 21, 21, 45, 31, 39, 22, 37, 21, 46, 62, 18, 38, 36, 41, 16, 36, 22, 37, 10, 8, 13, 19, 12, 19, 19, 9, 14, 11, 16, 21, 10, 13, 15, 6, 6, 6, 27, 11, 11, 19, 16, 14, 12, 13, 13, 11, 11.

Shippping times for expedited shipping (available for USA only), days: 6, 6, 6, 7, 9, 10, 9, 9, 9, 8, 9, 10, 7, 7, 10, 11, 10, 13, 11, 21, 17, 17, 15, 15, 18, 19, 17, 18, 15, 7, 9, 7, 12, 24, 29, 15, 10, 11, 8, 10, 8, 15, 20, 22, 8, 23, 6, 7, 21, 10, 13, 7, 7, 13, 10, 13, 10, 8, 9, 9, 7, 7, 7, 6, 9, 11, 9, 9, 7, 7, 8, 7, 8, 9, 8, 8, 8, 11, 8, 13, 12, 16, 16, 11, 11, 9, 11, 27, 8, 15, 12, 11, 11, 12, 11, 7, 8, 13, 11, 13, 20, 16, 18, 9, 8, 12, 8, 8, 14, 17, 20, 32, 16, 17, 17, 17, 38, 17, 24, 35, 36, 18, 24, 17(EMS), 19, 36, 26, 25, 25, 26, 26, 27, 31, 12, 17, 28, 13, 28, 28, 12, 29, 15, 11, 34, 26, 13, 15, 13, 23, 27, 16, 27, 28, 16, 16, 16, 16, 18, 18, 15, 15, 16, 19, 21, 13, 20, 13, 19, 20, 12, 15, 8, 14, 9, 21, 14, 13, 10, 15, 23, 15, 22, 20, 19, 23, 17, 18, 14, 12, 14, 15, 20, 15, 13, 15, 20, 20, 21, 36, 16, 14, 14, 10, 15, 21, 16, 16, 13, 13, 14, 14, 13, 13, 9, 10, 11, 10, 12, 40, 11, 16, 20, 11, 11, 10, 20, 9, 18, 18, 17, 25, 21, 26, 22, 13, 24, 24, 24, 13, 24, 24, 25, 18, 20, 26, 16, 16, 22, 23, 22, 30, 32, 26, 31, 9, 11, 124, 12, 25, 22, 20, 36, 24, 24, 25, 21, 27, 29, 29, 23, 22, 24, 27, 29, 28, 16, 23, 17, 22, 22, 14, 31, 26, 31, 31, 24, 31, 26, 16, 31, 20, 27, 19, 38, 13, 27, 20, 12, 19, 13, 13, 17, 22, 26, 10, 30, 19, 12, 11, 11, 13, 12, 12, 13, 20, 11, 12, 14, 16, 16, 11, 11, 11, 31, 14, 55(EMS), 53(EMS), 14, 14, 31, 97, 45, 11, 13, 14, 11, 13, 11, 14, 11, 14, 37, 14, 37, 37, 38, 26, 87, 38, 28, 28, 39, 29, 17, 40, 17, 20, 41, 27, 26, 27, 27, 18, 20, 27, 25, 8, 20, 32, 11, 28, 15, 23, 23, 17, 17, 16, 25, 65, 19, 25, 27, 24, 22, 23, 21, 7, 19, 15, 25, 23, 15, 18, 18, 26, 19, 25, 25, 24, 18, 24, 26, 22, 27, 21, 25, 27, 28, 28, 24, 25, 18, 20, 17, 7, 24, 19, 14, 14, 14, 14, 19, 19, 14, 9, 11, 16, 31, 12, 13, 22, 13, 14, 15, 14, 10, 11, 11, 11, 12, 14, 14, 16, 15, 13, 15, 15, 17, 20, 76, 27, 19, 19, 20, 20, 29, 28, 25, 21, 28, 29, 30, 18, 18, 34, 14, 23, 14, 9, 18, 11, 9, 18, 10, 33, 42, 17, 10, 42, 16, 28, 11, 12, 10, 12, 29, 11, 29, 11, 13, 12, 47, 16, 11, 46, 20, 6, 8, 7, 5, 12, 9, 21, 7, 9, 19, 10, 7, 11, 10, 10, 11, 19, 7, 22, 16, 18, 9, 7, 7, 9, 8, 11, 12, 12, 10, 13, 11, 12, 10, 14, 10, 15, 12, 6, 17, 15, 7, 18, 8, 10, 9, 11, 12, 15, 15, 12, 15, 11, 20, 21, 15, 22, 15, 18, 13, 11, 9, 23, 29, 10, 10, 6, 6, 8, 23, 7, 8, 9, 6, 7, 7, 7, 11, 10, 10, 6, 27, 7, 7, 8, 8, 8, 14, 8, 11, 12, 7, 7, 7, 12, 7, 9, 24, 8, 9, 10, 7, 7, 12, 8, 7, 6, 7, 7, 9, 7, 9, 10, 10, 6, 11, 7, 9, 14, 20, 7, 6, 9, 7, 7, 9, 6, 8, 8, 7, 7, 6, 7, 9, 7, 7, 9, 6, 7, 7, 8, 8, 7, 6, 7, 9, 11, 11, 10, 9, 10, 7, 15, 6, 7, 10, 7, 10, 8, 14, 11, 7, 10, 8, 11, 9, 12, 12, 19, 7, 12, 23, 17, 16, 8, 11, 11, 11, 7, 6, 7, 12, 14, 13, 9, 8, 9, 9, 11, 11, 10, 7, 11, 9, 9, 10, 14, 8, 7, 10, 13, 8, 12, 7, 12, 8, 8, 9, 10, 9, 7, 7, 13, 6, 9, 13, 10, 10, 9, 10, 9, 9(EMS), 17, 8, 9, 7, 7, 7, 7, 11, 9, 11, 12, 6, 7, 8, 5, 8, 8, 6, 9, 7, 7, 11, 7, 9, 8, 8, 7, 7, 6, 10, 6, 6, 8, 8, 6, 6, 9, 7, 9, 9, 12, 7, 8, 8, 8, 8, 8, 12, 8, 11, 8, 7, 6, 10, 10, 9, 12, 10, 12, 12, 9, 8, 9, 10, 10, 8, 11, 7, 6, 7, 9, 9, 7, 8, 8, 8, 9, 10, 9, 7, 6, 23, 7, 7, 10, 9, 9, 13, 12, 11, 10, 11, 7, 6, 10, 11, 7, 8, 9, 9, 9, 7, 7, 8, 8, 10, 8, 7, 8, 7, 10, 8, 9, 10, 10, 6, 10, 9, 10, 10, 6, 8, 6, 9, 13, 12, 11, 10, 25, 11, 9, 9, 9, 9, 11, 11, 11, 8, 8, 10, 13, 11, 10, 8, 8, 8, 9, 9, 9.

If you haven't a preferred dosage then I usually advise for MtF 7 mg (0.18 ml) every 5 days, each vial for 9 months. This dosage gives average blood estradiol level as from oral estradiol about 20 mg/day, but is much less expensive, 35 times less expensive than the cheapest estradiol pills in InHousePharmacy. This dosage is enough high to suppress testosterone production by testicles completely without antiandrogens. 7 USD/month for safe highly effective MtF HRT.

You may wonder why so cheap - no, it's estradiol in pharmacies what's overpriced. Cost of estradiol is less than 1% of pharmacy prices for pills. Also, only 5% of oral (swallowed) estradiol reaches blood. In other words, injected estradiol is 20 times more effective than swallowed. Don't worry, I do make a profit.

You can inject with insulin syringes (1 ml or less) with inbuilt (fixed, non-detachable) needles 1/2" - 5/8" (12-16 mm) long into the upper outer quarter of a buttock (deep subcutaneous).

About safety: I use terminal heat sterilization: I heat already mixed solution in sealed vials in an autoclave under pressure 165 kPa = 24 PSI at temperature 129úC (overkill - more than recommended 121úC) for 30 min. Bacteria, fungi, viruses cannot survive that. Bureaucrats get their salary for inventing new rules, no matter how unreasonable. I was accused that I don't follow rules for American compounding pharmacies like special workspace with controlled airflow and 0.22 micron filtering. However, the accuser doesn't want to think that chemical factories sell hormone powders non-sterilized. What's the sense to use controlled airflow and filtering if one of ingredients is not sterile, and filtering doesn't stop viruses? Anyway terminal sterilization must be used, and I do use it. Any efforts before terminal sterilization are pointless because the powder is not sterile, I sterilize everything as the final stage. I can understand filtering of solution for intravenous infusions liters per day (in ICU), but filtering of low-volume (1 ml/month) solution for subcutaneous or intramuscular injections doesn't make sense. If a speck of dust lands in one of hundred vials, is sterilized with heat and injected, nothing happens. An abscess is collection of pus, pus is caused by infection, a sterilized speck of dust cannot infect. For the paranoid I offer 0.22 micron filtering into sealed pre-sterilized vials (of solution in MCT oil), but it's more expensive (+10 USD per vial) and slightly less solution volume per vial because of dead space in filters. If you shake up a vial, air bubbles appear. Larger bubbles soon float up, burst and disappear. But tiniest bubbles float in the solution for days. It's very difficult to distinguish a tiny air bubble from a particle.

If you want, instead of vials with ready-to-use solution I can send you vials with estradiol valerate powder 400 mg/vial for 40 USD/vial, a vial with a solvent, a vial with a preservative and detailed instructions how to mix them and sterilize.

I offer also ready-to-use solution of estradiol enanthate (shortly EEn to distinguish it from ethinylestradiol - EE) 500 mg/vial (10 ml/vial 50 mg/ml) in Castor or MCT oil for 80 USD/vial. Estradiol enanthate is longer-acting than estradiol valerate. I advise 0.22 ml weekly or 0.31 ml every 10 days. The price difference between EV and EEn is $1/month, but it's easier to not forget if you inject (EEn) on the same day of every week. You can choose with solvent/thinner (faster goes through thin needle) or without. The solvent sometimes (seldom) causes allergy. One more variant is with neither solvent nor preservative.

Another option is ready-to-use solution of estradiol valerate 50 mg and progesterone 250 mg, 20 USD/vial, 8 to 16 vials per packet. Custom EV/P ratio is possible, or EV + hydroxyprogesterone caproate.

Ask me any questions via email Lena@lena.kiev.ua, specify the country you are living in (payment options depend on country).

Lena