Inexpensive DIY MtF HRT

I began MtF HRT in 1989, had SRS in 1999. Injectable estradiol valerate and transdermal estradiol don't affect liver and blood clotting at all, but transdermals are much more expensive. When I was on factory-made injectable estradiol valerate, I developed an allergy to some impurity in it. Because of that, I began to compound injectable estradiol valerate for myself by myself at home: I mix estradiol valerate powder, a preservative (antibacterial) and a solvent (all pharmaceutical quality, from pharmaceutical trade companies) in multi-dose vials, add Castor oil from a pharmacy or MCT oil 99.9% (you can choose, MCT oil is less viscous but Castor oil gives more stable blood estradiol level) and sterilize sealed vials. After I tested on myself, in 2006 I began to sell to other MtF. In October 2017 I began to ship worldwide.

I sell ready-to-use vials with estradiol valerate solution 400 mg/vial (10 ml/vial 40 mg/ml) sterilized at 129úC for 60 USD/vial, 2 to 8 vials per purchase, currently expiration November 2026. Shipping to most countries 8 USD, tracked. For example, last shipping times to USA: 12, 12, 15, 13, 13, 14, 16, 16, 16, 16, 19, 18, 16, 16, 14, 12, 16, 15, 13, 13, 11, 14, 17, 11, 15, 13, 11, 12, 14, 11, 14, 12 days;
to UK 17, 17, 18, 15, 19, 16, 10, 13, 11, 12, 13, 11, 15, 11, 14, 14, 12, 9, 13, 14, 15 days;
to Germany 12, 14, 12, 10, 7, 11 days;
to France 14, 18, 18, 12, 8, 11, 10 days;
to Netherlands 17, 16, 18, 11, 14, 12, 15 days.

If you haven't a preferred dosage then I usually advise for MtF 7 mg (0.18 ml) every 5 days, each vial for 9 months. This dosage gives average blood estradiol level as from oral estradiol about 20 mg/day, but is much less expensive, 35 times less expensive than the cheapest estradiol pills in InHousePharmacy. This dosage is enough high to suppress testosterone production by testicles completely without antiandrogens. 7 USD/month for safe highly effective MtF HRT.

You may wonder why so cheap - no, it's estradiol in pharmacies what's overpriced. Cost of estradiol is less than 1% of pharmacy prices for pills. Also, only 5% of oral (swallowed) estradiol reaches blood. In other words, injected estradiol is 20 times more effective than swallowed. Don't worry, I do make a profit.

You can inject with insulin syringes (1 ml or less) with inbuilt (fixed, non-detachable) needles 1/2" - 5/8" (12-16 mm) long into the upper outer quarter of a buttock (deep subcutaneous).

About safety: I use terminal heat sterilization: I heat already mixed solution in sealed vials in an autoclave under pressure 165 kPa = 24 PSI at temperature 129úC (overkill - more than recommended 121úC) for 30 min. Bacteria, fungi, viruses cannot survive that. Bureaucrats get their salary for inventing new rules, no matter how unreasonable. I was accused that I don't follow rules for American compounding pharmacies like special workspace with controlled airflow and 0.22 micron filtering. However, the accuser doesn't want to think that chemical factories sell hormone powders non-sterilized. What's the sense to use controlled airflow and filtering if one of ingredients is not sterile, and filtering doesn't stop viruses? Anyway terminal sterilization must be used, and I do use it. Any efforts before terminal sterilization are pointless because the powder is not sterile, I sterilize everything as the final stage. I can understand filtering of solution for intravenous infusions liters per day (in ICU), but filtering of low-volume (1 ml/month) solution for subcutaneous or intramuscular injections doesn't make sense. If a speck of dust lands in one of hundred vials, is sterilized with heat and injected, nothing happens. An abscess is collection of pus, pus is caused by infection, a sterilized speck of dust cannot infect. For the paranoid I offer 0.22 micron filtering into sealed pre-sterilized vials (of solution in MCT oil), but it's more expensive (+10 USD per vial) and slightly less solution volume per vial because of dead space in filters. If you shake up a vial, air bubbles appear. Larger bubbles soon float up, burst and disappear. But tiniest bubbles float in the solution for days. It's very difficult to distinguish a tiny air bubble from a particle.

If you want, instead of vials with ready-to-use solution I can send you vials with estradiol valerate powder 400 mg/vial for 40 USD/vial, a vial with a solvent, a vial with a preservative and detailed instructions how to mix them and sterilize.

I offer also ready-to-use solution of estradiol enanthate (shortly EEn to distinguish it from ethinylestradiol - EE) 500 mg/vial (10 ml/vial 50 mg/ml) in Castor or MCT oil for 80 USD/vial. Estradiol enanthate is longer-acting than estradiol valerate. I advise 0.22 ml weekly or 0.31 ml every 10 days. The price difference between EV and EEn is $1/month, but it's easier t1o not forget if you inject (EEn) on the same day of every week. You can choose with solvent/thinner (faster goes through thin needle) or without. The solvent sometimes (seldom) causes allergy. One more variant is with neither solvent nor preservative.

Since July 2023 I offer also the most long-acting (injections every 3-4 weeks) estradiol undecylate 600 mg/vial (10 ml/vial 60 mg/ml) in Castor or MCT oil for 100 USD/vial, or 1000 mg/vial in Castor oil with solvent/thinner (20% BB) for 160 USD/vial.

Another option is ready-to-use solution of estradiol valerate 50 mg and progesterone 250 mg, 20 USD/vial, 8 to 16 vials per packet. Custom EV/P ratio is possible, or EV + hydroxyprogesterone caproate.

Testimonials: a girl here in Kiev gave me this;
blood tests.

If you are attentive then you can DIY.

Ask me any questions via email Lena@lena.kiev.ua, specify the country you are living in (payment options depend on country).

Lena