Inexpensive DIY MtF HRT

I began MtF HRT in 1989, had SRS in 1999. Injectable estradiol valerate and transdermal estradiol don't affect liver and blood clotting at all, but transdermals are much more expensive. When I was on factory-made injectable estradiol valerate, I developed an allergy to some impurity in it. Because of that, I began to compound injectable estradiol valerate for myself by myself at home: I mix estradiol valerate powder, a preservative (antibacterial) and a solvent (all pharmaceutical quality, from pharmaceutical trade companies) in multi-dose vials, add Castor oil from a pharmacy or less viscous ethyl oleate 99.3% (you can choose) and sterilize sealed vials. After I tested on myself, in 2006 I began to sell to other MtF. In October 2017 I began to ship worldwide.

I sell ready-to-use vials with estradiol valerate solution 400 mg/vial (10 ml/vial 40 mg/ml) sterilized at 129úC for 60 USD/vial, 2 to 8 vials per purchase, currently expiration June 2024. Shipping 7 USD. Every my packet was successfully received. For example, delivery to USA with USPS registered mail, tracked, in 20, 12, 16, 11, 11, 13, 14, 16, 14, 10, 8, 7, 12, 7, 9, 15, 13, 9, 10, 8, 10, 11, 10, 8, 8, 10, 11, 14, 14, 18, 21, 25, 20, 8, 26, 21, 18, 28, 15, 16, 18, 22, 23, 18, 19, 20, 21, 33, 26, 22, 18, 26, 26, 19, 18, 18, 28, 20, 21, 18, 15, 13, 12, 16, 11, 16, 20, 19, 21, 13, 14, 16, 12, 21, 23, 12, 12, 22, 14, 13, 16, 16, 16, 13, 11, 37, 14, 14, 17, 13, 13, 13, 13, 13, 16, 24, 24, 20, 13, 14, 18, 17, 15, 14, 17, 12, 15, 13, 14, 15, 19, 13, 11, 14, 14, 14, 17, 11, 9, 10, 11, 10, 20, 8, 16, 11, 10, 17, 11, 11, 25, 11, 15, 11, 11, 15, 11, 12, 11, 11, 11, 7, 9, 8, 6, 9, 20, 11, 11, 8, 8, 8, 9, 7, 6, 10, 7, 8, 12, 5, 7, 10, 6, 7, 7, 10, 7, 8, 8, 8, 8, 10, 12, 12, 7, 12, 8, 9, 7, 9, 7, 7, 9, 10, 8, 7, 10, 6, 9, 10, 7, 11, 6, 9, 9, 8, 7, 6, 8, 7, 7, 7, 9, 9, 6, 7, 11, 6, 7, 8, 10, 10, 11, 11, 13, 9, 8, 11, 7, 11, 11, 8, 8, 8, 13, 14, 9, 8, 14, 13, 9, 11, 10, 7, 11, 9, 13, 10, 12, 11, 12, 24, 12, 15, 15 days.

If you haven't a preferred dosage then I usually advise to MtF 7 mg (0.18 ml) every 5 days, each vial for 9 months. This dosage gives average blood estradiol level as from oral estradiol about 20 mg/day, but is much less expensive, 35 times less expensive than the cheapest estradiol pills in InHousePharmacy. This dosage is enough high to suppress testosterone production by testicles completely without antiandrogens. 7 USD/month for safe highly effective MtF HRT.

You may wonder why so cheap - no, it's estradiol in pharmacies what's orverpriced. Cost of estradiol is less than 1% of pharmacy prices for pills. Also, only 5% of oral (swallowed) estradiol reaches blood. In other words, injected estradiol is 20 times more effective than swallowed. Don't worry, I do make a profit.

You can inject with insulin syringes (1 ml or less) with inbuilt (fixed, non-detachable) needles 1/2" - 5/8" (12-16 mm) long into the upper outer quarter of a buttock (deep subcutaneous).

About safety: I use terminal heat sterilization: I heat already mixed solution in sealed vials in an autoclave under pressure 165 kPa = 24 PSI at temperature 129úC (overkill - more than recommended 121úC) for 30 min. Bacteria, fungi, viruses cannot survive that. Bureaucrats get their salary for inventing new rules, no matter how unreasonable. I was accused that I don't follow rules for American compounding pharmacies like special workspace with controlled airflow and 0.22 micron filtering. However, the accuser doesn't want to think that chemical factories sell hormone powders non-sterilized. What's the sense to use controlled airflow and filtering if one of ingredients is not sterile, and filtering doesn't stop viruses? Anyway terminal sterilization must be used, and I do use it. Any efforts before terminal sterilization are pointless because the powder is not sterile, I sterilize everything as the final stage. I can understand filtering of solution for intravenous infusions liters per day (in ICU), but filtering of low-volume (1 ml/month) solution for subcutaneous or intramuscular injections doesn't make sense. If a speck of dust lands in one of hundred vials, is sterilized with heat and injected, nothing happens. An abscess is collection of pus, pus is caused by infection, a sterilized speck of dust cannot infect. For the paranoid I offer 0.22 micron filtering into sealed pre-sterilized vials (currently of solution in grapeseed oil), but it's more expensive (+10 USD per vial) and slightly less solution volume per vial because of dead space in filters. If you shake up a vial, air bubbles appear. Larger bubbles soon float up, burst and disappear. But tiniest bubbles float in the solution for days. It's very difficult to distinguish a tiny air bubble from a particle.

If you want, instead of vials with ready-to-use solution I can send you vials with estradiol valerate powder 400 mg/vial for 40 USD/vial, a vial with a solvent, a vial with a preservative and detailed instructions how to mix them and sterilize.

I offer also ready-to-use solution of estradiol enanthate (shortly EEn to distinguish it from ethinylestradiol - EE) 500 mg/vial (10 ml/vial 50 mg/ml) in ethyl oleate (or Castor oil) for 80 USD/vial. Estradiol enanthate is longer-acting than estradiol valerate. I advise 0.22 ml weekly or 0.31 ml every 10 days. My EEn is just 16% more expensive per month (7.65 USD/month) than my EV (6.57 USD/month).

Another option is ready-to-use solution of estradiol valerate 50 mg and progesterone 250 mg, 20 USD/vial, 8 to 16 vials per packet. Custom EV/P ratio is possible, or EV + hydroxyprogesterone caproate.

Ask me any questions via email Lena@lena.kiev.ua, specify the country you are living in (payment options depend on country).

Lena